Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling

Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk.Here ORG GENMAI MISO we set out to examine the role of this pseudokinase in atherosclerotic plaque development.Human endarterectomy atherosclerotic tissue specimens analysed by immunofluor

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Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria

Abstract The non-filarial and non-communicable disease podoconiosis affects around 4 million people and is characterized by severe leg lymphedema accompanied with painful intermittent acute inflammatory episodes, called acute dermatolymphangioadenitis (ADLA) attacks.Risk factors have been associated with the disease but the mechanisms of pathophysi

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Oxygen therapy for sepsis and prevention of complications

Patients with COMPASS sepsis have a wide range of respiratory disorders that can be treated with oxygen therapy.Experimental data in animal sepsis models show that oxygen therapy significantly increases survival, while clinical data on the use of different oxygen therapy protocols are ambiguous.Oxygen therapy, especially hyperbaric oxygenation, in

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